Protein Details: Glutamate [NMDA] receptor subunit 1

Protein ID

ICDB_Pro_0094

Protein Name

Glutamate [NMDA] receptor subunit 1

Gene Name

Nmdar1; GK23704

Organism

Drosophila willistoni (Fruit fly)

Length

982 amino acids

AlphaFoldDB

AF-B4MU83-F1-model_v4.pdb

Function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity

Sequence

MAFAVWFLSTFVIVAAQRHMALEHEGTYNIGGVLTNSDSEEHFRTTIAHLNFDQQYVPRKVTYYEKTIRMDKNPIKTVFNVCNKLIEKRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFSYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVEMIVEFEPKLTSFSEHLTYMKTAQSRVYLMYASTEDAQIIFRDARDHNMTQEGHVWIVTEQALFANNTPEGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKTRNITGETGQVAFDDNGDRIYAGYDVINIRENQKQHVVGKFSYDNMRAKMRMKINDSEIIWAGKQKRKPEGIMIPTHLKLLTIEEKPFVYVRRMGDDEFHCEPNERPCPLFNTTDATANEFCCSGYCIDLLIELAKRINFTYDLALSPDGQFGHYILRNNTGATLRKEWTGLIGQLVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEHAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSRAPGTISLAVDKKRYPRLSQRMGPERAWPGDAAEVLRMRRPYEIGKPGQSPKVIGGPPHPMLGKTRPQAQQNLLPPRYSPGYTSDVSHLVV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

518..520;525;691;735

Disease

Location

DOI ID

10.1038/nature06341

RefSeq

XP_002064686.1